Clarification Statement - S.HS.LS.1.3.CS:
Examples of investigations could include heart rate response to exercise, stomate response to moisture and temperature, and root development in response to water levels.

Assessment Boundary - S.HS.LS.1.3.AB:
Assessment does not include the cellular processes involved in the feedback mechanism.

Science and Engineering Practices - 9-12.SEP3.1:
Plan and conduct an investigation individually and collaboratively to produce data to serve as the basis for evidence, and in the design: decide on types, how much, and accuracy of data needed to produce reliable measurements and consider limitations on t

Disciplinary Core Ideas - S.HS.LS.1.3.DCI:
LS1.A: Structure and Function •Feedback mechanisms maintain a living system’s internal conditions within certain limits and mediate behaviors, allowing it to remain alive and functional even as external conditions change within some range. Feedback mechanisms can encourage (through positive feedback) or discourage (negative feedback) what is going on inside the living system. •(NYSED) Disease is a failure of homeostasis. Organisms have a variety of mechanisms to prevent and combat disease. Technological advances including vaccinations and antibiotics have contributed to the prevention and treatment of disease.

Crosscutting Concepts - CC6.8:
Feedback (negative or positive) can stabilize or destabilize a system.