Clarification Statement - S.HS.LS.1.4.CS:
Emphasis should be on the outcomes of mitotic division and cell differentiation on growth and development of complex organisms and possible implications for abnormal cell division (cancer) and stem cell research.

Assessment Boundary - S.HS.LS.1.4.AB:
Assessment does not include specific gene control mechanisms or rote memorization of the steps of mitosis.

Science and Engineering Practices - 9-12.SEP2.3:
Use a model based on evidence to illustrate the relationships between systems or between components of a system.

Disciplinary Core Ideas - S.HS.LS.1.4.DCI:
LS1.B: Growth and Development of Organisms •In multicellular organisms individual cells grow and then divide via a process called mitosis, thereby allowing the organism to grow. The organism begins as a single cell (fertilized egg) that divides successively to produce many cells, with each parent cell passing identical genetic material (two variants of each chromosome pair) to both daughter cells. Cellular division and differentiation produce and maintain a complex organism, composed of systems of tissues and organs that work together to meet the needs of the whole organism.

Crosscutting Concepts - CC3.8:
Models (e.g., physical, mathematical, computer models) can be used to simulate systems and interactions—including energy, matter, and information flows—within and between systems at different scales.